7.5 Safety data from over 1,200 patients-years of methotrexate and/or etanercept treatment in children with polyarticular or systemic juvenile rheumatoid arthritis
نویسندگان
چکیده
Address: 1Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA, 2Albert Einstein College of Medicine, Bronx, NY, USA, 3Children's Hospital and Reginal Medical Center, Seattle, WA, USA, 4Duke University Medical Center, Durham, NC, USA, 5Childrens Hospital of Los Angeles, Los Angeles, CA, USA, 6Ohio State University and Children's Hospital, Columbus, OH, USA, 7Schneider Children's Hospital, New Hyde Park, NY, USA and 8Amgen, Thousand Oaks, CA, USA * Corresponding author
منابع مشابه
Etanercept therapy in children with juvenile rheumatoid arthritis.
Etanercept is an effective inhibitor of tumor necrosis factor that has shown a beneficial effect in patients with juvenile rheumatoid arthritis (JRA) that did not respond to other disease-modifying drugs. Here we report 3 patients with JRA who were refractory to traditional therapy; 1 with systemic JRA and 2 with polyarticular JRA. They received etanercept 0.4 mg/kg (maximum 25 mg) subcutaneous...
متن کاملSerial measurements of soluble interleukin 2 receptor levels (sIL2-R) in children with juvenile rheumatoid arthritis treated with oral methotrexate.
OBJECTIVE To investigate the potential clinical utility of serial levels of sIL2-R as a marker of disease activity among children with juvenile rheumatoid arthritis (JRA) treated with methotrexate (MTX). METHODS sIL2-R levels, measured by ELISA, were evaluated in 16 JRA patients (10 polyarticular, six systemic-onset) treated with oral, weekly MTX. sIL2-R values were compared with those of 49 ...
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Background: Antiphospholipid antibody syndrome (APS) can either occur as a primary syndrome or associated with other autoimmune diseases such as systemic lupus erythematosus (SLE). Anticardiolipin antibody (aCL) of IgG and/or IgM isotype in blood, measured by a standardized ELISA is the most acceptable laboratory criteria. APS IgG isotype, particularly IgG2 subclass is more strongly associated ...
متن کاملClinical utility of etanercept in the treatment of arthritides in children and adolescents
Juvenile idiopathic arthritis (JIA) is a group of chronic inflammatory diseases affecting approximately 300,000 children and adolescents in the United States of unknown cause. It can affect children from the age of 0 years up to the age of 16 years. The International League of Associations of Rheumatology has defined seven subsets of JIA based on several factors including the number of affected...
متن کاملLong term follow-up after sudden withdrawal from a multicentric study of abatacept in juvenile idiopathic arthritis – data from the Portuguese cohort
Results Eight patients (7M/1F) with mean age of 16.5 years (range 13-19years) and disease duration of 8,6years (range 1,5-13years) were followed. All patients had polyarticular involvement only partially responsive to methotrexate (extended oligoarticular (OE)-3, polyarticular Rheumatoid factor IgM negative (Poly)-2, systemic onset (SoJIA)-3). Concurrent therapies, maintained after the abatacep...
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